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Hippo Conference 2023 Program |
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Venue: Auditorium, Level 2, Matrix, Biopolis, 30 Biopolis Street,
Singapore 138671 |
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as of 11 Oct |
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Wednesday, 1 November 2023 (Day 1) |
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08:30 - 09:30 |
Arrival of Guests and Registration |
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WELCOME COFFEE & TEA |
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09:30 - 09:40 |
WELCOME ADDRESS BY ORGANISERS |
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Wanjin HONG, Institute of Molecular and Cell Biology,
A*STAR, Singapore |
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Kieran HARVEY, Peter MacCallum Cancer Centre, Australia |
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09:40 - 09:45 |
Introduction of Opening Keynote (Chair: Kieran HARVEY) |
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09:45 - 10:30 |
OPENING KEYNOTE
(Chair: Kieran HARVEY) |
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Georg HALDER, VIB-KU Leuven Center for Cancer Biology,
Belgium |
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"2023: A Hippo Odyssey" |
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Session 1: The Hippo Pathway in Development (Chair: Kun-Liang GUAN,
Westlake University, China) |
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10:30 - 11:00 |
Nic TAPON, The Francis Crick Institute, UK |
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"Developmental Modulation of Tissue Growth by the Hippo
Pathway" |
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11:00 - 11:30 |
Yingzi YANG, Harvard University, USA |
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"Yap Regulation of Shh Expression as a Common Mechanism
Underlying both Bone Diseases and Neural Tube Patterning" |
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11:30 - 12:00 |
Iswar HARIHARAN, University of California, Berkeley,
USA |
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"Biological Functions of the Hippo Pathway" |
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12:00 - 14:00 |
LUNCH AND POSTER SESSION 1 |
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14:00 - 14:30 |
Dae-Sik LIM, KAIST, Korea
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"Decoding the Hippo-YAP/TAZ Signaling Axis in Adipocyte
Plasticity" |
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14:30 - 15:00 |
Bin ZHAO, Zhejiang University, China |
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"RIPK4 Promotes Epidermal Differentiation through Phosphorylation
and Activation of LATS1/2" |
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15:00 - 15:15 |
Short Talk: Ines CABRITA,
University of Cologne, Germany |
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"The Impact of Phase-separated Condensates Formed by YAP and TAZ
for Podocyte Biology and Glomerular Diseases" |
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15:15 - 15:30 |
Short Talk: Xaralabos VARELAS, Boston University,
USA |
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"YAP/TAZ Control Apical Cytoskeletal Organization and Planar
Polarity in Multiciliated Cells" |
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15:30 - 16:00 |
AFTERNOON COFFEE & TEA |
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Session 2: Hippo and Transcription (Chair: Kunxin LUO, University
of California, Berkeley, USA) |
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16:00 - 16:30 |
Jeff WRANA, Lunenfeld-Tanenbaum Research Institute,
Canada |
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"TGFbeta and Hippo Convergence During Intestinal Regeneration" |
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16:30 - 17:00 |
Chunling YI, Georgetown University, USA |
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"Title to be advised" |
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17:00 - 17:30 |
Zhaocai ZHOU, Fudan University, China |
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"The Hippo Signaling Pathway in Gastric Cancer" |
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17:30 - 17:45 |
Short Talk: Maxim FROLOV,
University of Illinois at Chicago, USA |
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"Combined Inactivation of RB and Hippo Pathways Converts
Differentiating Photoreceptors |
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17:45 - 18:00 |
Short Talk: Matthew FRANKLIN,
University of California San Diego, USA |
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"Human Satellite DNA Arrays as a Novel Hub for Hippo
Transcription Factors YAP and TEAD" |
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END OF DAY 1 |
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Thursday, 2 November 2023 (Day 2) |
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08:45 - 09:30 |
KEYNOTE 2 (Chair:
Nic TAPON, The Francis Crick Institute, UK) |
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Stefano PICCOLO, University of Padova, Italy |
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"Regulation and Function of Yap/Taz in Cancer and Aging" |
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Session 3: Hippo and Mechanotransduction
(Chair: Nic TAPON, The Francis Crick Institute, UK) |
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09:30 - 10:00 |
Helen McNEILL, Washington University School of Medicine in St. Louis, USA |
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"The Nuclear Envelope in Mechanoresponses" |
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10:00 - 10:30 |
Ken IRVINE, Rutgers University, USA |
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"Regulation of Hippo Signaling by Jub:
Biomechanics to Biocondensates" |
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10:30 - 11:00 |
MORNING COFFEE & TEA (+ Photo-taking) |
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11:00 - 11:30 |
Liliana ATTISANO,
University of Toronto, Canada |
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"The Role of NUAKs in Cancer and Fibrosis" |
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11:30 - 12:00 |
Manvendra K. SINGH,
Duke-NUS Medical School, Singapore |
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"Role of Hippo Signalling Mediators Yap/Taz in Inflammation and
Fibrosis" |
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12:00 - 12:15 |
Short Talk: Wonyoung JEONG, University of Seoul, Korea |
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"RAI14 Links Mechanical Forces to Hippo Signaling" |
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12:15 - 12:30 |
Short Talk: Lars HOLMGREN,
Karolinska Institutet, Sweden |
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"Endothelial Junctional Mechanotransduction
in Aortic Aneurysm Formation: Insights and Significance" |
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12:30 - 14:10 |
LUNCH AND POSTER SESSION 2 |
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14:10 - 14:30 |
Lunch-time Talk by Chen Ying,
Institute of Molecular and Cell Biology, A*STAR, Singapore (Collaborator of MGI Tech Singapore) |
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"High Resolution Spatial Profiling – Stereoseq" |
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Session 4: Hippo and Signal Transduction (Chair: Helen McNEILL, Washington University School of Medicine in
St. Louis, USA) |
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14:30 - 15:00 |
Xuelian LUO, UT Southwestern Medical Center, USA |
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"Structural Analysis of the Human STRIPAK" |
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15:00 - 15:30 |
Fa-Xing YU, Fudan University, China |
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"Two Guardians of the Hippo Village" |
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15:30 - 15:45 |
Short Talk: Katrina MITCHELL, Peter
MacCallum Cancer Centre, Australia |
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"Neoplastic Tumours are Prevented by AP-1 Mediated Repression of
Hippo Pathway Target Genes" |
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15:45 - 16:00 |
Short Talk: Wenqi WANG, University of California, Irvine, USA |
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"The Hippo Pathway Noncanonically Regulates Heavy Metal Response
and Chemotherapy" |
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16:00 - 16:30 |
AFTERNOON COFFEE & TEA |
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16:30 - 17:00 |
Kun-Liang GUAN, Westlake University, China |
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"Hippo Signaling and Cancer" |
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17:00 - 17:30 |
Dawang ZHOU, Xiamen University, China |
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"Title to be advised" |
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17:30 - 17:45 |
Short Talk: Chen-Ying LIU, Xinhua
Hospital, Shanghai Jiao Tong University School of Medicine, China |
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"YAP/TAZ Enhance P-body Formation to Promote Tumorigenesis" |
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17:45 - 18:00 |
Short Talk: Shuwei ZHANG, Tsinghua University, China |
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"Targeting TFF3 Inhibits YAP-regulated EGFR TKI Resistance in
Lung Adenocarcinoma" |
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END OF DAY 2 |
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18:15 |
Bus Departure from Matrix to Conference Dinner (for invited Speakers +
Participants who registered for Dinner) |
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19:00 |
CONFERENCE DINNER (for Invited Speakers + Participants who registered
for Dinner) |
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21:15 |
Bus Departure from Conference Dinner to Park Ave Rochester Hotel (for
Invited Speakers + Guests staying at the Hotel) |
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Friday, 3 November 2023 (Day 3) |
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Session 5: Hippo and Cancer (Chair: Wenqi
WANG, University of California, Irvine, USA) |
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09:00 - 09:30 |
Brian RUBIN, Cleveland Clinic, USA |
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"Lessons Learned from the Study of Epithelioid Hemangioendothelioma, a TAZ-CAMTA1/TEAD Addicted
Cancer" |
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09:30 - 10:00 |
Anwesha DEY, Genentech, USA |
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"Targeting the Hippo Pathway in Cancers" |
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10:00 - 10:15 |
Short Talk: Nilanjana CHATTERJEE, University
of California San Francisco, USA |
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"Targeting Hippo-YAP, BET and RAS-MAPK Interplay in Lung Cancer
to Forestall Drug Resistance" |
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10:15 - 10:30 |
Short Talk: Madhura KULKARNI, Center For Translational Cancer Research - IISER Pune and PCCM
Pune, India |
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"Role of YAP in HER2-mediated Tumorigenesis" |
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10:30 - 11:00 |
MORNING COFFEE & TEA |
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Session 6: Therapeutic Targeting of the Hippo Pathway
(Chair: Anwesha DEY, Genentech, USA) |
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11:00 - 11:30 |
Mien-Chie HUNG, China Medical University, Taiwan |
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"Marker-guided Effective Therapy (Mget):
YAP as a Therapeutic Target involving Ribose-phosphate and MRCK" |
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11:30 - 11:45 |
Short Talk: Tracy TANG, Vivace
Therapeutics, USA |
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"Targeting Cancer with VT3989 the First-in-class and
First-in-human TEAD Auto-palmitoylation Inhibitor" |
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11:45 - 12:00 |
Short Talk: Timo HEINRICH, Merck
Healthcare KGaA, Germany |
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"Tuning TEAD Paralog Selectivity Within Same Chemical Motive and
HDX Based MoA Investigations of P-Site Binding TEAD
Inhibitor" |
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12:00 - 12:15 |
Short Talk: Emilie CHAPEAU,
Novartis Institutes for BioMedical Research and
Global Drug Development, Switzerland |
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"IAG933, A Selective and Orally Efficacious YAP1/TAZ‐panTEAD Protein‐Protein Interaction Inhibitor with
Pre‐Clinical Activity |
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12:15 - 12:30 |
Short Talk: Ajaybabu POBBATI, Cleveland Clinic, USA |
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"Cyclin-dependent Kinases are a Vulnerability that can be
Targeted in Epithelioid Hemangioendothelioma" |
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12:30 - 14:30 |
LUNCH AND POSTER SESSION 3 |
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Session 7: Hippo, Stem Cells and Organogenesis (Chair: Bob VARELAS, Boston
University, USA) |
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14:30 - 15:00 |
James MARTIN, Baylor College of Medicine, USA |
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"Hippo-Signaling in Heart Regeneration" |
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15:00 - 15:30 |
Hongyan WANG, Duke-NUS Medical School, Singapore |
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"Waking Up “Sleeping” Neural Stem Cells" |
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15:30 - 15:45 |
Short Talk: Benjamin KROEGER, Monash
University, Australia |
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"Basal Spot Junctions of Epithelial Tissues Respond to
Morphogenetic Forces and Regulate Hippo Signalling" |
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15:45 - 16:00 |
Short Talk: Bjoern VON EYSS, Leibniz
Institute on Aging - Fritz Lipmann Institute, Germany |
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"Translational Mouse Models Demonstrate the Proof-of-concept of
Anti-YAP/TAZ Cancer Therapy" |
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16:00 - 16:30 |
AFTERNOON COFFEE & TEA |
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16:30 - 17:15 |
CLOSING KEYNOTE (Chair: Wanjin HONG) |
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Duojia PAN, UT Southwestern Medical Center, USA |
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"Hippo Signaling in a Unicellular Relative of Animals" |
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17:15 - 17:45 |
PRIZE PRESENTATIONS & CONFERENCE CLOSING REMARKS BY ORGANISERS
(Wanjin HONG & Kieran HARVEY) |
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END OF DAY 3 |
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